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Network studies based on ‘omics’ data.

This area of research deals with the study of the mechanism of action of bioactive molecules, which are involved in the prevention of diseases and the maintenance of well-being. The research is based on new cellular (2D/3D) and animal models as well as biological fluids, quantitatively evaluating the expression of proteins, lipids, and metabolites, and providing a detailed description of the changes in the biological system following treatment. Through network analysis, the research identifies the involved signaling and metabolic pathways. The quantitative ‘omics’ approaches are based on advanced analytical methodologies: separation techniques (nano liquid chromatography, affinity chromatography, one- and two-dimensional protein electrophoresis), high-resolution tandem mass spectrometry, and bioinformatics and statistical analysis.

  • Baron G., Altomare A., Della Vedova L., Gado F., Quagliano O., Casati S., Tosi N., Bresciani L., Del Rio D., Roda G., D’Amato A., Lammi C., Macorano A., Vittorio S., Vistoli G., Fumagalli L., Carini M., Leone A., Marino M., Del Bo’ C., Miotto G., Ursini F., Morazzoni P., Aldini G. Unraveling the parahormetic mechanism underlying the health-protecting effects of grapeseed procyanidins. Redox Biol. 2024 Feb;69:102981. doi: 10.1016/j.redox.2023.102981. Epub 2023 Dec 7.
  • Moreto F, Garcia JL, Ferreira ALDA, Radrezza S, Costa MR, Romualdo GR, Grandini NA, Aldini G, Correa CR, D’Amato A. Quantitative proteomics study of carnosine effect in an animal model of Western diet-induced nonalcoholic fatty liver disease. J Biochem Mol Toxicol. 2024 Feb;38(2):e23644. doi: 10.1002/jbt.23644.
  • Zoanni B, Aiello G, Negre-Salvayre A, Aldini G, Carini M, D’Amato A. Lipidome Investigation of Carnosine Effect on Nude Mice Skin to Prevent UV-A Damage. Int J Mol Sci. 2023 Jun 11;24(12):10009. doi: http://10.3390/ijms241210009.
  • Ferrario G., Baron G., Gado F., Della Vedova L., Bombardelli E., Carini M., D’Amato A., Aldini G., Altomare A. Polyphenols from Thinned Young Apples: HPLC-HRMS Profile and Evaluation of Their Anti-Oxidant and Anti-Inflammatory Activities by Proteomic Studies. Antioxidants 2022 Aug 15;11(8):1577. doi: http://10.3390/antiox11081577.
  • Nukala S.B., Tura-Ceide O., Aldini G., Smolders V.F.E.D., Blanco I., Peinado V.I., Castellà M., Barberà J.A., Altomare A., Baron G., Carini M., Cascante M., D’Amato A. Protein network analyses of pulmonary endothelial cells in chronic thromboembolic pulmonary hypertension. Sci Rep. 2022 Feb 10;12(1):2283. doi: http://10.1038/s41598-022-06238-z.