{"id":1063,"date":"2024-05-16T10:11:27","date_gmt":"2024-05-16T08:11:27","guid":{"rendered":"https:\/\/phanlab.unimi.it\/?page_id=1063"},"modified":"2024-08-25T18:46:46","modified_gmt":"2024-08-25T16:46:46","slug":"protein-oxidation-and-carbonylation-processes-using-proteomics-and-mass-spectrometry-techniques","status":"publish","type":"page","link":"https:\/\/phanlab.unimi.it\/en\/research\/protein-oxidation-and-carbonylation-processes-using-proteomics-and-mass-spectrometry-techniques\/","title":{"rendered":"Protein oxidation and carbonylation processes using proteomics and mass spectrometry techniques"},"content":{"rendered":"\n<p>The research topic is aimed at the identification and characterisation of new pharmacological targets and biomarkers of oxidative and carbonyl-based degenerative processes. Research in this area focused on the development and application of LC-MS\/MS and immunohistochemical methodologies for the identification of post-translational modifications of peptides and proteins in different biological matrices as early biomarkers of oxidative\/carbonyl damage.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Pubblicazioni<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Altomare A., Brioschi M., Eligini S., Bonomi A., Zoanni B., Iezzi A., Jemos C., Porro B., D&#8217;Alessandra Y., Guarino A., Omodeo Sal\u00e8 E., Aldini G., Agostoni P., Banfi C. <strong>N-Acetylcysteine Regenerates In Vivo Mercaptoalbumin<\/strong>. <em>Antioxidants<\/em> 2022 Sep 6;11(9):1758. doi: <a href=\"http:\/\/10.3390\/antiox11091758\">10.3390\/antiox11091758<\/a>.<\/li>\n\n\n\n<li>Altomare A., Baron G., Giannazza E., Banfi C., Carini M., Aldini G.&nbsp;<strong>Lipid peroxidation derived reactive carbonyl species in free and conjugated forms as an index of lipid peroxidation: limits and perspectives<\/strong>. <em>Redox Biol<\/em>. 2021 Jun:42:101899. doi: <a href=\"http:\/\/10.1016\/j.redox.2021.101899\">10.1016\/j.redox.2021.101899<\/a>.<\/li>\n\n\n\n<li>Altomare A., Baron G., Balbinot M., Pedretti A., Zoanni B., Brioschi M., Agostoni P., Carini M., Banfi C., Aldini G.&nbsp;<strong>In-depth age and ale profiling of human albumin in heart failure: Ex vivo studies<\/strong>.&nbsp;<em>Antioxidants<\/em> 2021 Feb 27;10(3):358. doi: <a href=\"http:\/\/10.3390\/antiox10030358\">10.3390\/antiox10030358<\/a>.<\/li>\n\n\n\n<li>Mol M., Degani G., Coppa C., Baron G., Popolo L., Carini M., Aldini G., Vistoli G., Altomare A. <strong>Advanced lipoxidation end products (ALEs) as RAGE binders: Mass spectrometric and computational studies to explain the reasons why<\/strong>. <em>Redox Biol<\/em>. 2019 May;23:101083. doi: <a href=\"http:\/\/10.1016\/j.redox.2018.101083\">10.1016\/j.redox.2018.101083<\/a>.<\/li>\n\n\n\n<li>Aldini G,. Regazzoni L., Orioli M., Rimoldi I., Facino R.M., Carini M. <strong>A tandem MS precursor-ion scan approach to identify variable covalent modification of albumin Cys34: A new tool for studying vascular carbonylation<\/strong>. <em>J Mass Spectrom<\/em>. 2008 Nov;43(11):1470-81. doi: <a href=\"http:\/\/10.1002\/jms.1419\">10.1002\/jms.1419<\/a>.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>The research topic is aimed at the identification and characterisation of new pharmacological targets and biomarkers of oxidative and carbonyl-based degenerative processes. Research in this area focused on the development and application of LC-MS\/MS and immunohistochemical methodologies for the identification of post-translational modifications of peptides and proteins in different biological matrices as early biomarkers of [&hellip;]<\/p>\n","protected":false},"author":282,"featured_media":1173,"parent":1029,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1063","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/phanlab.unimi.it\/en\/wp-json\/wp\/v2\/pages\/1063"}],"collection":[{"href":"https:\/\/phanlab.unimi.it\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/phanlab.unimi.it\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/phanlab.unimi.it\/en\/wp-json\/wp\/v2\/users\/282"}],"replies":[{"embeddable":true,"href":"https:\/\/phanlab.unimi.it\/en\/wp-json\/wp\/v2\/comments?post=1063"}],"version-history":[{"count":1,"href":"https:\/\/phanlab.unimi.it\/en\/wp-json\/wp\/v2\/pages\/1063\/revisions"}],"predecessor-version":[{"id":1065,"href":"https:\/\/phanlab.unimi.it\/en\/wp-json\/wp\/v2\/pages\/1063\/revisions\/1065"}],"up":[{"embeddable":true,"href":"https:\/\/phanlab.unimi.it\/en\/wp-json\/wp\/v2\/pages\/1029"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/phanlab.unimi.it\/en\/wp-json\/wp\/v2\/media\/1173"}],"wp:attachment":[{"href":"https:\/\/phanlab.unimi.it\/en\/wp-json\/wp\/v2\/media?parent=1063"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}